Synthetic Route of 328-73-4,Some common heterocyclic compound, 328-73-4, name is 1-Iodo-3,5-bis(trifluoromethyl)benzene, molecular formula is C8H3F6I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of bisallene (1 equiv), aryl/heteroaryl iodide (2.4 equiv), nucleophile (2.4 equiv), Pd2(dba)3 (5 molpercent), TFP (tri-(2-furyl)phosphine) (20 mol percent) and K2CO3 (6 equiv) in MeCN (5 mL) was stirred and heated at 80¡ãC (oil bath temperature). The mixture was filtered through a filter paper and the K2CO3 precipitate washed with MeCN (5 mL). The solvent was removed under reduced pressure, the residue dissolved in CHCl3 and washed with H2O (1¡Á20 mL). The organic layer was dried (anhydrous MgSO4), filtered and the filtrate evaporated under reduced pressure. The residue was purified by flash chromatography. 4.2.4. 1,3-Bis[(2Z)-4-(8-fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-3-(1H-indol-5-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione (14d). Prepared by general procedure B and heating for 1h. The solvent was cooled to precipitate the cascade product, filtered and the precipitate washed with water to dissolve K2CO3. The product 14d (0.12 g, 58 percent) crystallized from CHCl3 as pale yellow needles, mp 175?177¡ãC; deltaH (300 MHz, DMSO-d6); 11.06 (1H, br s, NH), 10.01 (1H, br s, NH), 10.86 (1H, s, NH), 10.84 (1H, s, NH), 7.80 (1H, d, J 7.9, pyrimidinyl?H), 7.70 (1H, s, Ar?H), 7.64 (1H, s, Ar?H), 7.32?7.18 (8H, m, Ar?H), 7.08 (1H, t, J 2.8, Ar?H), 7.05 (1H, t, J 2.6, Ar?H), 6.79 (2H, br t, J 9.2, Ar?H), 6.36 (2H, br s, Ar?H), 5.96 (1H, t, J 6.4, NCH2CH=), 5.79 (1H, t, J 6.5, NCH2CH=), 5.70 (1H, d, J 7.2, pyrimidinyl?H), 4.75 (2H, d, J 7.2, NCH2CH=), 4.72 (2H, d, J 7.2, NCH2CH=), 3.78 (4H, s, 2¡Á =CCH2N), 3.63 (4H, s, 2¡Á pyridoindolyl?CH2), 2.83 (4H, br s, 2¡Á pyridoindolyl?CH2), 2.69 (4H, br s, 2¡Á pyridoindolyl?CH2); numax/cm?1 (film); 3406, 1697, 1649, 1453, 1391, 1323, 1231; m/z (ESI+) 827.4 (100percent, MH+); (found MH+, 827.3640. C50H45F2N8O2 requires 827.3628).
The synthetic route of 328-73-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Elboray, Elghareeb E.; Aly, Moustafa F.; Abbas-Temirek, Hussien H.; Churchill, Gwydion H.; Grigg, Ronald; Tetrahedron; vol. 70; 1; (2014); p. 110 – 122;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com