Adding a certain compound to certain chemical reactions, such as: 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68507-19-7, Formula: C8H7IO3
PyBop (675mg, 1.297mmol) and DIPEA (0.3mL) was added to a 0C solution of diamine (127mg, 1.174mmol) and acid (360mg,.1.295mmol) in DMF (3.0mL) under nitrogen. The solution was slowly warmed to room temperature. After 24 hours, the reaction solution was poured into saturated aqueous NaHC03 (20mL) and extracted with EtOAc (2x20mL). The organic layer was washed with brine(2x20mL), dried over MgSO,, filtered and concentrated. The crude solid was purified on a Combiflash Rf using Si02 with CH2CI2/MeOH to afford 367mg (85%) of amide product as a white solid. A suspension of the amide (294mg, 0.779mmol) in AcOH (8.0mL) was heated to reflux. After 24 hours, the solution was cooled to room temperature and concentrated in vacuo to a tan solid. The crude solid was purified via Combiflash Rf using Si02 with CH2CI2/Me0H to afford 2-(3-iodo-4-methoxyphenyl)- 1 H-benzo[d]imidazole (193mg, 69%) as a colorless solid.
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Reference:
Patent; REGENTS OF THE UNIVERSITY OF MINNESOTA; HARRIS, Reuben S.; HARKI, Daniel A.; PERKINS-HARKI, Angela L.; CARPENTER, Michael A.; LI, Ming; WO2013/74059; (2013); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com