Synthetic Route of 35944-64-0, The chemical industry reduces the impact on the environment during synthesis 35944-64-0, name is 3-Iodo-4-methylaniline, I believe this compound will play a more active role in future production and life.
Triethylamine (8 mL) was added to a degassed solution of 5-ethynylpyrimidin-2-amine (Intermediate 18) (1.19 g), 3-iodo-4-methylaniline (2.6 g), PdCl2 (PPh3) 2 (100 mg) and Cul (15 mg) in DMF (40 mL) and the mixture heated to 60C for 90 minutes, cooled and concentrated in vacuo. The residue was dissolved in methanol, filtered, and concentrated in vacuo. Purification by flash chromatography on silica using 0-10% MeOH in DCM gave the title compound as a pale yellow solid (1.60 g, 70%, contaminated with 0.3 moles of Et3NHI).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-4-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/60970; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com