Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Iodo-2-(trifluoromethyl)benzene
General procedure: A mixture of aryl iodide (2 mmol), CuI (0.10 mmol), ligand(1.1 mmol), and S8 (1.1 mmol) were added to an oven-driedreaction tube equipped with a septum. The reaction tube wasevacuated and back-filled with argon. Under a counterflowof argon, EIPA (0.258 g, 2 mmol) and DMSO (2 mL) wereadded, and the mixture stirred at r.t. for 8 h. After completedisappearance of aryl iodide (monitored by TLC), H2O (5mL) was added, and the mixture was extracted with CH2Cl2(3 ¡Á 5 mL). The combined organic phases were dried (onMgSO4) and filtered before evaporation of the solvent. Theresidue was purified on silica gel, eluting with PE?EtOAc(20:1), to give product 2. Analytical and spectroscopic datafor all derivatives, except 2g?i have been reported previously.19
The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yavari, Issa; Ghazanfarpour-Darjani, Majid; Solgi, Yazdan; Synlett; vol. 25; 8; (2014); p. 1121 – 1123;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com