Adding a certain compound to certain chemical reactions, such as: 35674-27-2, name is 4-Iodo-3-nitrobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35674-27-2, name: 4-Iodo-3-nitrobenzoic acid
b) 4-Iodo-3-nitro-benzoic acid methyl ester A methanolic solution of 4-iodo-3-nitro-benzoic acid (10.0 g, 34.13 mmol, 1 eq. ) was treated with concentrated sulfuric acid (7 mL) and the reaction heated to reflux. After 6 hours, the acid was neutralized with solid sodium bicarbonate and the methanol removed in vacuo. The residual oil was diluted with water and extracted with diethyl ether. Combined the organics, washed with brine, dried, filtered, and removed the solvent in vacuo leaving an orange oil which was purified via normal phase chromatography to leave 4-iodo-3-nitro-benzoic acid methyl ester (8.08 g, 77% yield) as a yellow solid.
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Reference:
Patent; ELI LILLY AND COMPANY; WO2005/40157; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com