These common heterocyclic compound, 755027-21-5, name is 4-Chloro-1-iodo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 755027-21-5
Example 60A 4-CHLORO-2-METHOXYBENZONITRILE A mixture of Example 59A (2.68g, 10 mmol), Zn (CN) 2 (0.654g, 5.5 mmol), and Pd (PPh3) 4 (0. 577G, 0.5 mmol) in DMF (15 mL) was stirred at 90 C for 6 hours and cooled to room temperature. The reaction mixture was poured into water (500 ML) and extracted with ethyl acetate several times. The combined extracts were washed with water and brine, dried (MGS04), filtered, and concentrated under vacuum. The residue was purified by flash column chromatography on silica gel with 9: 1 hexanes/ethyl acetate to provide 1.34g (90%) of the desired product. MS (DCI) m/e 168 (M+H) ; H NMR (300 MHz, CDC13) 8 7.49 (d, J = 8.1 Hz, 1H), 6.97-7. 03 (m, 2H).
The synthetic route of 4-Chloro-1-iodo-2-methoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; WO2004/76424; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com