Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-methoxy-2-methylbenzene
General procedure: Similar conditions for performing a Negishi coupling reaction with 15 have previously been described.4 A round bottom flask plus stir bar were dried and flushed with Ar before adding 1-iodo-3-isopropylbenzene (0.404 g, 1.64 mmol; purchased from Combi-Blocks) and anhyd. DMF (3 mL). Reaction was vacuum purged and refilled with Ar (3x) before the addition of Pd2dba3 (50 mg, 0.16 mmol) and P(o-tolyl)3 (75 mg, 0.082 mmol). A suspension containing organozinc 15 (5.5 mL, 2.5 mmol, 1.5 equiv.) was carefully added via syringe so as to avoid aspirating unreacted zinc metal. Reaction was stirred overnight at room temperature under Ar. Reaction mixture was quenched with sat. NH4Cl and extracted with EtOAc (2 x 15 mL). Organic phase was washed with brine, dried over MgSO4, filtered, concentrated and dried under high vacuum. Crude was purified by flash chromatography eluting with 5% EtOAc/Hexanes resulting in a beige solid: 277 mg (42%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75581-11-2.
Reference:
Article; Augustyn, Evan; Finke, Karissa; Zur, Arik A.; Hansen, Logan; Heeren, Nathan; Chien, Huan-Chieh; Lin, Lawrence; Giacomini, Kathleen M.; Colas, Claire; Schlessinger, Avner; Thomas, Allen A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 11; (2016); p. 2616 – 2621;,
Iodide – Wikipedia,
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