Electric Literature of 191348-14-8, These common heterocyclic compound, 191348-14-8, name is 2-Iodo-4-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-iodo-4-methoxyaniline 30-d ( 1.00 g, 4.02 mmol) in DMF cooled to 0C were sequentially added diethylamine (419 uL, 4.02 mmol), copper(I) iodide (143 mg, 0.80 mmol) and dichlorobis(triphenylphosphine) palladium (II) (282 mg, 0.40 mmol). After complete dissolution of copper(I)iodide, propyl 3,3-dimethylhex-5-ynoate 1 1-d (805 mg, 4.42 mmol) was added dropwise at 0C and the reaction was then stirred at room temperature overnight. Water and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous ammonium chloride and brine, dried over anhydrous MgS04, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 30-e as a beige oil. MS (m/z) M+H=304
The synthetic route of 191348-14-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMASCIENCE INC.; BUREAU, Patrick; FOURNIER, Jean-Hugues; JAQUITH, James B.; LAURENT, Alain; ROSE, Yannick; PROULX, Melanie; MORRIS, Stephen; WO2012/126084; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com