60577-34-6, name is 4-Iodo-N-methylaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 60577-34-6
To a 250?mL round-bottomed flask equipped with a magnetic stir bar was added 4-iodo-N-methylaniline (2, 35.0?g, 150? mmol, 1 equiv) and 100?mL DCM. tBuONO (26.8?mL, 225?mmol, 1.5 equiv) was added dropwise into the flask under ice bath in 15?min. Then the reaction was allowed to proceed under stirring at r.t. for 4?h until the completion of reaction. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography on silica gel with PE/EA (4:1) as the eluent and recrystallized in PE and DCM. The product 3 was obtained as a light yellow solid in 94% yield (37.0?g, 141?mmol). 1H NMR (500?MHz, CDCl3) delta 7.82-7.77 (m, 2H), 7.34-7.29 (m, 2H), 3.42 (s, 3H). 13C NMR (126?MHz, CDCl3) delta 142.01, 138.50, 120.53, 91.62, 30.97.
The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Zhongsu; Zeng, Hua; Zhang, Wenjing; Song, Chao; Yang, Fan; Liu, Yun; Zhu, Jin; Polymer; vol. 172; (2019); p. 152 – 159;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com