Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-76-7, name is 1-Chloro-3-iodopropane, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
Solution stirred between -20 an’d 1 0 C for 30 min and subsequently cooled to -78 C. A solution of tert-butyl 6-chloropyridin-2-ylcarbamate (108; 57.0g, 0.249mol) in TH F (300mL) was added over 1 5 min. The reaction mixture was aged for 1 hour and then Cul (47.6g, 0.249mol) was added in one portion. The reaction mixture was al lowed to warm to – 1 0 C for one hour. 1 – Chloro-3-iodopropane (76.5g, 0.374 mol) was added neat over a period of 1 min, the cooling bath was removed and reaction allowed to warm to ambient temp and subsequently refluxed overnight. Upon completion of the reaction, the reaction mixture was cooled and quenched via addition of saturated sodium bicarbonate. The aqueous layer was extracted with EtOAc, The combined organic layers were dried over a2S04, filtered through a short si lica gel pad, concentrated to afford crude product., Triturated with ether to afforded tert-butyl 7-chloro-3,4- dihydro- l ,8-naphthyridine- l (2H)-carboxylate (109; 43g, yield 67%). M S (ESI) calcd for C,3H17C1N202 (m/z) 268.74.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com