Application of 2265-93-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2265-93-2, name is 2,4-Difluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of (3S)-piperidin-3-ol hydrochloride (0.50 g, 0.0036 mol), l,3-difl’uoro-4- iodobenzene (0.522 mL, 0.00436 mol), copper(I) iodide (140 mg, 0.00073 mol), potassium phosphate (3.08 g, 0.0145 mol), and 1 ,2-ethanediol (0.810 mL, 0.0145 mol) in 1-butanol (7.28 mL, 0.0796 mol) was heated at 100 0C under nitrogen for 2 nights. The reaction mixture was treated with water, and then extracted with EtOAc. The organic layers were combined, washed with brine, dried and evaporated to dryness. The residue was used directly in next step without further purifications (529 mg, 69%). LCMS (M+H): 214.2.
The chemical industry reduces the impact on the environment during synthesis 2,4-Difluoroiodobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; INCYTE CORPORATION; WO2007/89683; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com