Adding a certain compound to certain chemical reactions, such as: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18698-96-9, category: iodides-buliding-blocks
2-(2-Iodophenyl)acetamide (107-2). HATU (50.8 g, 134 mmol) was added to a stirred solution of 107-1 (28 g, 107 mmol), NH3 (321 ml, 160 mmol, 0.5 M/dioxane), iV-methylmorpholine (23.5 ml, 214 mmol) in . DMF (300 ml). The mixture was stirred for 16 hours and then was diluted with EtOAc and washed with H2O, sat NaHCO3, brine, dried over anhydrous MgSO4, filtered and 2/3 solvent was removed in vacuo. The solid was collected, washed with diethyl ether and dried in vacuo to afford 29-2 11.2g, 40.2percent) as a white solid.1H NMR (500 MHz, CDCl3) delta7.i (d, 1 H, J = 8 Hz), 7.36 (m, 2 H), 7.00 (m, 1 H), 5.38 (s, 2 H), 3.75 (s, 2H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; MERCK & CO., INC.; WO2008/51532; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com