Application of 5326-47-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5326-47-6, name is 2-Amino-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.
2-Amino-5-iodoben- zoic acid (0.6616 g, 2.52 mmol) was refluxed overnight in CH3OH with TMSC1 (1.3689 g, 12.60 mmol) to esteriFy the carboxylic group. The solvent was evaporated. Afier that EtOAc was added, and it was extracted with saturated NaHCO3, water, and brine solution. After that it was purified with column chromatography (5% EtOAc in hexane) to yield yellow solid (3 9.29%). ?H-NMR (500 MHz, CDC13) oe 8.14 (d, J=2.2 Hz, 1H), 7.47 (dd, J=8.7, 2.2 Hz, 1H), 6.46 (d, J=8.7 Hz, 1H), 3.86 (s, 3H); ?3C-NMR (126 MHz, CDC13) oe 167.5, 149.9, 142.4, 139.6, 119.0, 113.0, 76.1, 51.9. Theterminal alkyne was prepared by method described above and purified by column chromatography (5% EtOAc in hexane) to obtain yellow solid (84.78%). Then, itwas desilylated before purification by column chromatography (10% EtOAc in hexane) to obtain pale yellow solid(50.72%).
The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-iodobenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE SCRIPPS RESEARCH INSTITUTE; MAHIDOL UNIVERSITY; TAYLOR, Palmer; YAMAUCHI, John; TALLEY, Todd T.; ARUNRUNGVICHIAN, Kuntarat; VAJRAGUPTA, Opa; FOKIN, Valery; (79 pag.)US2018/244653; (2018); A1;,
Iodide – Wikipedia,
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