Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41252-95-3, name is 1-Chloro-4-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Chloro-4-iodo-2-nitrobenzene
To a jacketed reactor, N,N-dimethylacetamide (DMAc) (960 mL) and sodium methylate (Na- OMe) powder (77.8 g) is charged at 20 C. Dimethyl malonate (191 g) is added dropwise into the above mixture while keeping internal temperature at around 10 C. After finishing addition, warm up the mixture to 20 C, and continue to stirr for another 10 minutes. Then, 2-chloro-5- iodonitrobenzene (136 g) is added in one portion, and heat the mixture to 78 C and stir for usually at least 2.5 hours until process monitor shows almost complete conversion. The resulting mixture is cooled down to 20 C, and it is quenched by 2 N cold aq. HCI solution (1440 mL). Then, the mixture is stirred for another 1 hour. Collect the solid by filtration and wash the solid with water (500 mL) to afford 2-(4-iodo-2-nitrobenzene)-dimethlymalonate (146 g) as pale yellow solid in 80% yield and 97% HPLC purity (Rt = 13.9 min).1H NMR (400 MHz, CDCI3) delta 3.79 (s, 6H), 5.26 (s, 1 H), 7.25-7.27 (m, 1 H), 7.95-7.98 (dd, J = 8.3, 1 .8 Hz, 1 H), 8.36-8.37 (d, J = 1 .8 Hz, 1 H);13C NMR (100 MHz, CDCI3) delta 53.3, 53.6, 93.4, 127.4, 132.8, 133.8, 142.4, 148.9, 167.1 ; MS (ESI): m/z 378.96 (M+1 ).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41252-95-3.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM INTERNATIONAL TRADING (SHANGHAI) CO., LTD.; SHI, Wenjian; SONG, Yanli; BAO, Yuhui; LU, Jun; HUANG, Yao; WEBER, Dirk; WO2014/37307; (2014); A1;,
Iodide – Wikipedia,
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