Synthetic Route of 333447-42-0, These common heterocyclic compound, 333447-42-0, name is 1,5-Difluoro-2-iodo-4-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B – Synthesis of Compound CC2; A solution of compound CCl (7.11 g, 28.0 mmol), zinc cyanide (1.97 g, 16.8 mmol) and tetrakis(triphenylphosphine)palladium(0) (3.23 g, 2.80 mmol) in DMF (30 mL) was heated to 900C and allowed to stir at this temperature for 1.5 hours. The reaction mixture was concentrated in vacuo and the residue obtained was taken up in water (400 mL) and extracted with ether (400 mL). The organic extract was washed with aqueous ammonium hydroxide solution (IN). The organic layer was dried (MgSO4) filtered, concentrated in vacuo to provide a residue that was purified using flash column chromatography (SiO2, EtOAc/Hexanes) to provide a mixture that contained product and triphenylphosphine. This mixture was further purified using sublimation at 1 mm/Hg at 45 0C to provide compound CC2 (1.8 g; Yield = 42%).
Statistics shows that 1,5-Difluoro-2-iodo-4-methylbenzene is playing an increasingly important role. we look forward to future research findings about 333447-42-0.
Reference:
Patent; SCHERING CORPORATION; WO2008/82484; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com