Adding a certain compound to certain chemical reactions, such as: 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 401-81-0, SDS of cas: 401-81-0
To a solution of 1-trifluoromethyl-3-iodobenzene 13 (20 g, 73.5 mmol) in THF (200 mL) was added Pd(PPh3)2Cl2 (1.3 g, 0.18 mmol) and CuI (0.35 g, 0.18 mmol). Nitrogen was passed through the mixture while stirring for 20 minutes. Propargyl alcohol (4.9 g, 88.2 mmol) was added to the mixture followed by triethylamine (8.9 g, 88.2 mmol). The resulting exothermic reaction raised the temperature of the mixture to approximately 40 C. which was maintained with external heating for 2 hr, then the reaction mixture was stirred overnight. The mixture was cooled to room temperature, diluted with MTBE (200 mL) and filtered through a pad of Celite. The filtrate was washed with brine (200 mL), dried over sodium sulfate and solvent was removed under reduced pressure. The crude product was purified by column chromatography (200 g silica gel, eluted by 10-50% ethyl acetate/heptane gradient) to give the product 31 (14 g, 95% yield) as a yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-3-(trifluoromethyl)benzene, and friends who are interested can also refer to it.
Reference:
Patent; Liu, Julie F.; Imagire, Jillian; US2008/261926; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com