Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H6BrIO2
2 L reactor to the 2-bromo methyl benzoate agent 75 g (349 mmol), benzo [a] thiophene-2- boronic acid 80.7 g (453 mmol), tetrakis (triphenylphosphine) palladium, 10.1 g (9 mmol ), 120.5 g of potassium carbonate (872 mmol put), 1,4- dioxane, 370 mL, 370 mL toluene, 160 mL distilled water was stirred at 100 for 12 hours. After cooling to room temperature, and extracted with ethyl acetate and the organic layer. After concentration under reduced pressure the organic layer was separated by column chromatography to give the compound 80 g (yield: 85.9%) represented by the [intermediate 1-c].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SFC Co., Ltd; Sin, Bonggi; Park, Gyoung Hwa; Park, Ji-Hae; Park, Bubai; (51 pag.)KR2015/144120; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com