Reference of 627-31-6, A common heterocyclic compound, 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), molecular formula is C3H6I2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step-l : Synthesis of 2-(3-iodopropyl) isoindoline-l,3-dione (3444) [1194] To a suspension of potassium l,3-dioxoisoindolin-2-ide (3 g, 16.2 mmol) in DMF (150 mL) was added 1,3-diiodopropane (4.2 mL, 36.4 mmol) dropwise and heated at 85C for 2 h. The reaction mixture was monitored by LCMS. The reaction mixture was diluted with cold water and extracted with diethyl ether (2×250 mL). The combined organic layer was washed with water (3×200 mL) and brine (250 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by chromatography with 10% EtOAc in hexane as eluent to afford 3 g of 2-(3- iodopropyl) isoindoline-1 ,3-dione.
The synthetic route of 627-31-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David; CHAKRAVARTY, Sarvajit; RAI, Roopa; BERNALES, Sebastian; SATHE, Balaji Dashrath; URETA, Gonzalo; MCCULLAGH, Emma; WO2015/116707; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com