Application of 19099-54-8,Some common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, molecular formula is C9H11I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 5 mL flask, the catalyst MgO(at)PdCu (10 mg for ArI or 40 mgfor ArBr and ArCl), ArX (1 mmol), DABCO (168 mg, 1.5 mmol), andTBAB (322 mg, 1 mmol), for aryl chloride and DMF (2 mL) wereadded under argon atmosphere. The alkyne (1.5 mmol) was alsoadded and the resulting mixture was stirred at 60-120 C forappropriate reaction times (see Tables). Progress of reactions wasfollowed by GC. Then, the reaction mixture was cooled down toroom temperature and extracted with ethyl acetate (3 x 5 mL), the organic phase was washed with H2O (10 mL), dried and evaporated.The resulting residue was purified by column or plate chromatographyusing hexane and ethyl acetate as eluents.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-2-isopropylbenzene, its application will become more common.
Reference:
Article; Gholinejad, Mohammad; Bahrami, Maedeh; Najera, Carmen; Pullithadathil, Biji; Journal of Catalysis; vol. 363; (2018); p. 81 – 91;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com