In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18698-96-9 as follows. Computed Properties of C8H7IO2
A suspension of 2-iodophenyl acetic acid (1 g, 3.82 mmol), 4-bromobenzenethiol (0.722 g, 3.82 mmol), KOH (0.427 g, 7.63 mmol) and copper powder (24 mg, 0.38 mmol) in 2 mL of water, was allowed to react in microwave (conditions: 2.x.6 min, 180 W, T max=100¡ã C., P max=100 psi). The suspension obtained was dissolved in 2N aqueous solution of KOH and then filtered. The filtrate was acidified with 1N aq. HCl; the white precipitate was filtered, dried in vacuo, purified by trituration with acetone to give the pure acid 1-bis as white solid (1.16 g, 94percent).1H-NMR (CDCl3, 200 MHz): 7.44 (d, J=7 Hz, 1H); 7.36-7.26 (m, 5H); 7.01 (d, J=8.4 Hz, 2H); 3.86 (s, 2H).Anal. Calcd. for C14H11BrO2S (MW=323.2): C, 52.03; H, 3.43; Br, 24.72; O, 9.90; S, 9.92.
According to the analysis of related databases, 18698-96-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRACCO IMAGING SPA; US2009/239829; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com