Synthetic Route of 4028-63-1,Some common heterocyclic compound, 4028-63-1, name is 2,4,6-Trimethyliodobenzene, molecular formula is C9H11I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The cuprous iodide (24 mg, 0.12mmol) and tetrakis(triphenylphosphine)palladium (43 mg, 0.06 mmol) were loadedinto a Teflon-sealed flask. 2-iodo-1,3,5-trimethylbenzene (0.51 g, 2.08 mmol) andphenylacetylene (0.26 g, 2.5 mmol) were loaded into a separate flask and dissolved intriethylamine (40 mL). This solution was then cannula-transferred into the flaskcontaining the catalysts, the solution was briefly degassed under vacuum, and theflask was sealed. The mixture was stirred under nitrogen at 80 ¡ãC for 6 h. The crudeproduct was purified by column chromatography (SiO2, eluent: petroleum ether) togive 2g as a colorless liquid in 92.0percent yield. (0.42 g, 1.91 mmol). 1H NMR (300 MHz,CDCl3): 7.51-7.54 (m, 2H), 7.33 (d, J = 7.1 Hz, 3H), 6.88 (s, 2H), 2.47 (s, 6H), 2.28(s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4,6-Trimethyliodobenzene, its application will become more common.
Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com