Adding some certain compound to certain chemical reactions, such as: 455-13-0, name is 4-Iodobenzotrifluoride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-13-0. 455-13-0
General procedure: In a 10 mL glass tube was placed 4-iodotoluene (219 mg, 1 mmol), potassium thiocyanate (243 mg, 2.5 mmol), copper(I) oxide (43 mg, 0.3 mmol), tetrabutylammonium bromide (97 mg, 0.3 mmol), and water (1 mL). The mixture was stirred for 1 min before sealing the tube with a septum and placing the reaction mixture into the microwave cavity (CEM Discover). An initial microwave power of 150 W was used, the temperature being ramped from rt to 200 C where it was held for 60 min (caution: The water is heated well above its boiling point so all necessary precautions should be taken when performing such experiments. Vessels designed to withhold elevated pressures must be used. The microwave apparatus used here incorporates a protective metal cage around the microwave vessel in case of explosion. After completion of an experiment, the vessel must be allowed to cool to a temperature below the boiling point of the solvent before removal from the microwave cavity and opening to the atmosphere.). The reaction mixture was stirred continuously throughout. The reaction was run in triplicate. After allowing the three identical reaction mixtures to cool to rt, the vessels were opened and their contents poured into a separatory funnel and the tubes washed three times with ethyl acetate (approximately 3 mL each time) followed by two washes with water (5 mL each time). All washings were added to the separatory funnel along with an additional 20 mL of ethyl acetate. Typically an emulsion was formed after shaking; therefore brine (approximately 5 mL) was added to aid separation. The aqueous layer was extracted twice more with ethyl acetate (approximately 30 mL each time). The organic washings were combined, washed with deionized water (approximately 20 mL), collected, dried over MgSO4, and then the ethyl acetate removed in vacuo. Purification was accomplished by column chromatography (100% hexanes) affording the product as a white solid (152 mg, 48%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Iodobenzotrifluoride.
Reference:
Article; Kelly, Christopher B.; Lee, Christopher Xiang; Leadbeater, Nicholas E.; Tetrahedron Letters; vol. 52; 36; (2011); p. 4587 – 4589;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com