6828-35-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6828-35-9, name is 5-Chloro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows.
To a suspension of 5-chloro-2-iodoaniline (18.7 g, 0.074 mol, 1.0 eq.) in 500 mL of water was added hydroxylamine hydrochloride (18.5 g, 0.27 mol, 3.6 eq.), sodium sulfate (84.0 g, 0.59 mol, 8.0 eq.), chloral hydrate (14.7 g, 0.89 mol, 1.2 eq.) and 2N aqueous hydrochloric acid (25 mL). The mixture was stirred at 70 C for 18 h, then allowed to cool to room temperature. The resulting mixture was extracted with EtOAc (400 mL X 3) and the combined organic layers were dried (Na2S04), filtered and concentrated to afford compound 2 (17.0 g, 72.1% yield).
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Reference:
Patent; LUDWIG INSTITUTE FOR CANCER RESEARCH LTD; GAHMAN, Timothy; SHIAU, Andrew; KOLODNER, Richard; (234 pag.)WO2017/51251; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com