672-57-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 672-57-1 as follows.
Three point eight (3.8) ml of n-butyllithium (2.6 M hexane solution) was added dropwise to a mixture of 3.00 gof 1-chloro-2-iodo-4-(trifluoromethyl)benzene and 15 ml of tetrahydrofuran at -70C, followed by stirring for 30 minutes.Thereafter, a mixture of 1.69 g of N-methoxy-N-methyltrifluoroacetamide and 5 ml of tetrahydrofuran was added dropwisethereto at -70C. Subsequently, after the reaction mixture was stirred for 1 hour at room temperature, water was addedthereto, and extraction was performed using ethyl acetate. The organic layer was washed with saturated saline, driedover magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gelcolumn chromatography, thereby obtaining 1.66 g of 2,2,2-trifluoro-1-[2-chloro-5-(trifluoromethyl)phenyl]ethanone.
According to the analysis of related databases, 1-Chloro-2-iodo-4-(trifluoromethyl)benzene, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com