As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3268-21-1 name is 1,4-Diiodo-2,3,5,6-tetramethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 3268-21-1
The Suzuki coupling reaction of 4-bromo-2-phenylpyridine (I) with N-Boc-2-pyrroleboronic acid, using Pd(OAc)2 as the catalyst, was carried out in a glove box due to the air sensitivity of PtBu3, and afforded 4-bromo-2-(N-Boc-pyrrol-2-yl)pyridine (6) with good selectivity. This allowed the remaining Ar-Br bond to be utilised and converted into a boronic ester functional group (7) and mono-Suzuki coupled to 1,4-diiododurene to yield compound (8). The cross-linking group was attached to compound (8) via Suzuki coupling reaction with (4-(non-8-en-1-yloxy)phenyl)boronic acid to yield compound (9). Boc deprotection to give (10) and subsequent cyclometalation using lrCl3.3H20 in 2-ethoxyethanol/H20 at 110 C afforded DIM ER-2 that was converted to the cross-linkable bis-heteroleptic acac phosphor Ir(4- durph-2-pyrpy)2(acac) using acetylacetone and sodium carbonate in 2-ethoxyethanol at 9000.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Diiodo-2,3,5,6-tetramethylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; LOMOX LIMITED; JUDD, Luke; ALDRED, Matthew; KOCH, Gene C.; (71 pag.)WO2018/162880; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com