A common compound: 29289-13-2, name is 2-Iodo-4-methylaniline, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 29289-13-2
The compound 2-iodo-4-methyl-aniline (32.6 g, 0.14 mol) was completely dissolved in 300 mL of chloroform in a nitrogen atmosphere, and bromine (21.9 g, 0.14 mol) was added at 0 C., and stirred for 2 hours. The organic layer was extracted with 300 mL of a 1 molar solution of sodium thiosulphate, and then the organic layer was completely distilled and purified by column chromatography (chloroform / hexane) to prepare Compound 1-B (40.2 g, yield: 92%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 29289-13-2, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LG Chem, Ltd.; Yoon Hong-sik; Kang Yu-jin; Hong Wan-pyo; Kim Jin-ju; (261 pag.)KR2019/78541; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com