101335-11-9, Adding a certain compound to certain chemical reactions, such as: 101335-11-9, name is 2-Chloro-4-fluoro-1-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101335-11-9.
To a solution of 1 (30mg, 0.157mmol), 2 (81mg, 0.315mmol) and Cs2CO3 (256mg, 0.785mmol) in DMF (2mL) were added 1 mg of Pd(dba)2 and 1 mg of Xantphos. The suspension was degassed under vacuum and purged with N2 several times. The mixture was stirred at 120 C for 1hr. The reaction was quenched by adding water and extracted with EA. The combine organic phases were washed by water, brine, dried over anhydrous Na2SO4 and concentrated to dryness. The residue was purified by pre-TLC to obtain the title compound Compound 215 (6.15mg, yield: 12.3%). LCMS: m/z, 319.0(M+H)+; 1HNMR (d-CDCl3, 400MHz): delta 8.62-8.63 (m, 1H), 7.68-7.72 (m, 1H), 7.50-7.52 (m, 1H), 7.28-7.32 (m, 1H), 7.09-7.12 (m, 1H), 6.91-6.93 (m, 2H), 4.06-4.17 (m, 1H), 3.68-3.77 (m, 2H), 3.33-3.38 (m, 1H), 2.46-2.69 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-fluoro-1-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; BALDWIN, John J.; WU, Chengde; SHEN, Chunli; WO2014/124560; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com