1878-69-9, Adding a certain compound to certain chemical reactions, such as: 1878-69-9, name is 2-(3-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1878-69-9.
To a suspension of 2-(2-Amino-5-ethynyl-pyrimidin-4-yl)-1-methyl-4-oxo-1 ,4,6,7 -tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (1.56 g, 4.25 mmol) in degassed MeCN (25 ml), Cui (1 0% mol, 81 mg, 0.425 mmol),3-iodophenylacetic acid (1.17 g, 4.25 mmol), TEA (5.92 ml, 42.48 mmol) and PdCb(PPh3)2 (1 0% mol, 0.30 g, 0.425mmol) were added. The mixture was degassed for three times back filling with argon each time and let under stirring5 at r.t. for 1 h. The reaction was quenched with 2 N HCI (21.2 ml) and the solvent was removed under reducedpressure. The residue was suspended in water and the resulting solid was filtered and rinsed with water affording thetitle product and brownish solid (1.62 g, 76%).(ESI) m/z 502 [(M +H)+]. HRMS (ESI) calculated for C21H2sN505 [(M + H)+]502.2085; found 502.2074.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Iodophenyl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; MENICHINCHERI, Maria; ANGIOLINI, Mauro; BERTRAND, Jay Aaron; CARUSO, Michele; POLUCCI, Paolo; QUARTIERI, Francesca; SALOM, Barbara; SALSA, Matteo; ZUCCOTTO, Fabio; WO2014/72220; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com