5471-81-8, Adding a certain compound to certain chemical reactions, such as: 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5471-81-8.
Specific operation: In a 25 mL reaction flask equipped with a magnetic stirrer, a metal catalyst palladium acetate (6.7 mg, 0.03 mmol), triphenylphosphine (20.0 mg, 0.075 mmol) was added, S-2-bromophenyl-S-methyliminosulfanone (70.0 mg, 0.3 mmol), norbornene (56.4 mg, 0.6 mmol), potassium carbonate (82.8 mg, 0.6 mmol),Nitrogen protection (at least three nitrogen cycles), followed by a mixture of acetonitrile and N,N-dimethylformamide in a nitrogen stream (V/V=1, 3 ml)And methyl 4-iodo-3-methylbenzoate (99.4 mg, 0.36 mmol), closed vessel.The reaction solution was heated to 80 C. for about 12 h, and the reaction was complete by TLC.In the post-treatment, the reaction solution is first diluted with 15 ml of ethyl acetate, and then filtered through a sand funnel filled with silica gel.Remove inorganic substances such as catalysts and alkalis,The resulting filtrate was separated by flash column chromatography to give the pure product 5,7-dimethyldibenzo[c,e][1,2]thiazine-9-carboxylic acid methyl ester-5-oxide compound 3m. Yield: 87%.
According to the analysis of related databases, 5471-81-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangxi Normal University; Chen Zhiyuan; Zhou Hao; Wang Xiumei; (17 pag.)CN107987034; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com