A common compound: 612-55-5, name is 2-Iodonaphthalene, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 612-55-5
An appropriate amount of DMF was added to the reaction vessel and purged with nitrogen until the atmosphere was a nitrogen atmosphere. Then 100 mmol of the compound of the above formula (II), 200 mmol of the compound of the above formula (III)7 mmol of bis (triphenylphosphine) cuprous nitrate,100 mmol DABCO and 15 mmol promoter (a mixture of 13 mmol triethyloxonium tetrafluoroborate and 2 mmol AgBF4), warmed to 100 C and reacted at this temperature for 12 hours.After completion of the reaction, saturated brine was added to sufficiently wash the organic phase, the organic phase was separated, washed thoroughly with deionized water and extracted with ether. The upper organic layer was taken, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was passed through a silica gel column Chromatography. The eluent used for column chromatography was a mixture of chloroform and petroleum ether. The volume ratio of the two was 1: 3 to obtain the compound of formula (I). The yield was 95.6%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 612-55-5, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wuhan Jinlian Pharmaceutical Co., Ltd.; Dong Xiao; Jin Yunhe; Lu Jun; Zhu Benfa; (10 pag.)CN104529854; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com