The chemical industry reduces the impact on the environment during synthesis 627-32-7, name is 3-Iodo-1-propanol, I believe this compound will play a more active role in future production and life. 627-32-7
Example 31 Synthesis of OS-1-CA Conjugate 48 (FIG. 24) Compound 46 To a solution of oseltamivir carboxylic acid N-Boc derivative (64, 60 mg, 0.16 mmol) in MeOH (0.5 mL) was added KOH (6.87 mg, 0.17 mmol). The mixture was stirred at room temperature for 30 min, and then concentrated under reduced pressure. The residue was dissolved in DMF (0.5 mL), and then added 3-iodo-1-propanol (17 mL, 0.19 mmol). After stirring at 50 C. for 4 h, the mixture was evaporated under reduced pressure. The residues was dissolved in CH2Cl2 (10 mL) and extracted with 1 M HCl and brine, dried over MgSO4, concentrated under reduced pressure, and purified by flash silica gel column chromatography (EtOAc/hexane, 2:1) to afford compound 65 (50 mg, 72%). C22H38N2O7; white solid; mp 93-95 C.; TLC (EtOAc/n-hexane, 2:1) Rf=0.31; [alpha]D22=-81.9 (c=1.0, CH2Cl2); IR (film) 3309, 2964, 2935, 2878, 1686, 1536, 1458, 1392, 1368, 1295, 1255, 1172, 1057 cm; 1H NMR (400 MHz, CDCl3) delta 6.77 (1H, s), 5.88 (1H, d, J=8.8 Hz), 5.11 (1H, d, J=9.6 Hz), 4.28-4.31 (2H, m), 4.01-4.08 (1H, m), 3.95 (1H, d, J=7.2 Hz), 3.73-3.82 (1H, m), 3.70 (2H, t, J=6.0 Hz), 3.30-3.34 (1H, m), 2.72 (1H, dd, J=17.6, 5.2 Hz), 2.26 (1H, dd, J=18.0, 10.0 Hz), 1.97 (3H, s), 1.87-1.93 (2H, m), 1.47-1.57 (4H, m), 1.41 (9H, s), 0.85-0.91 (6H, m); 13C NMR (100 MHz, CDCl3) delta 170.9, 165.9, 156.2, 138.1, 128.8, 82.3, 79.5, 75.8, 61.8, 58.6, 54.6, 49.3, 31.5, 30.9, 28.4 (3*), 26.2, 25.7, 23.3, 9.7, 9.3; HRMS calcd for C22H39N2O7: 443.2757, found: m/z 443.2753 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 627-32-7. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Academia Sinica; Wong, Chi-Huey; Fang, Jim-Min; Liu, Kung-Cheng; Jan, Jia-Tsrong; Cheng, Yih-Shyun E.; Cheng, Ting-Jen R.; US2013/274229; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com