18698-96-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, A new synthetic method of this compound is introduced below.
2-lodophenylacetic acid (2.00 g, 7.63 mmol) was dissolved in dry THF (70 mL) and dry DMF (10 mL) under an atmosphere of nitrogen. To the solution were added 1 – hydroxybenzotriazole (1.134 g, 8.396 mmol) and EDCI (1 .609 g, 8.396 mmol) and /V,/V-diisopropylethylamine (5.318 mL, 30.53 mmol) and the reaction mixture was stirred at room temperature for 10 minutes. Ammonium carbonate (2.933 g, 30.53 mmol) was added in one portion, and the reaction was stirred room temperature for 7 hours. The volatiles were removed in vacuo and the residual solution was diluted with EtOAc (150 mL) and sat. aq. NaHC03 (100 mL). The layers were separated and the organic layer were washed with water (100 mL), brine (100 mL), dried (MgSO), filtered and concentrated in vacuo to give the title compound (138) (1.755 g, 88percent yield) as a beige solid; 1H NMR (400 MHz, cfe-DMSO) delta 7.82 (dd, J = 7.9, 0.9 Hz, 1 H), 7.42 (s, 1 H), 7.36 – 7.28 (m, 2H), 7.02 – 6.94 (m, 2H), 3.55 (s, 2H). LCMS Method C: Pi 4.77 min; m/z 262.0 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; HOLMES, Ian, Peter; BERGMAN, Ylva; LUNNISS, Gillian Elizabeth; NIKAC, Marica; CHOI, Neil; HEMLEY, Catherine Fae; WALKER, Scott Raymond; FOITZIK, Richard Charles; GANAME, Danny; LESSENE, Romina; WO2012/110773; (2012); A1;,
Iodide – Wikipedia,
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