25252-00-0, Adding a certain compound to certain chemical reactions, such as: 25252-00-0, name is 2-Bromo-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25252-00-0.
General procedure: To a solution of 0.5 g compound 3(0.10 mol) in 3 ml DMF, 3.3 mg (0.01 mol) of copper iodide, 0.57 gcesium carbonate (0.1 mol), 20 mg (0.01 mol) Tetrakis (triphenylphosphine)palladium(0) was added under nitrogen atomophere. Then arylhalide (4-12) 0.11 mol was added under nitrogen atm, the mass wasstirred for 8 hrs at 75 C under nitrogen atm. Reaction was completed asindicated by TLC and the reaction mass was filtered through cellite bed,washed the bed with ethyl acetate (10 ml). The product layer (Ethylacetate layer)was then washed with water 10.0 ml, sodium bi sulphite10 ml followed by saturated sodium chloride solution (5.0 ml) and driedover (Na2SO4). The solvent was distilled off and the resulting productwas purified by column chromatography using ethyl acetate and nhexaneto get the pure product (4a-l). Yield observed was around85-90% for all the derivatives.
According to the analysis of related databases, 25252-00-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Thangarasu; Thamarai Selvi; Manikandan; Bioorganic Chemistry; vol. 81; (2018); p. 468 – 480;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com