77317-55-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
PREPARATION 94 2-Amino-5-iodobenzyl alcohol STR205 A solution of diisobutylaluminium hydride (210 cm3 of a 1.5M solution in THF) was added at -30 to a stirred solution of methyl-2-amino-5-iodobenzoate (28.0 g) in THF (100 cm3) under nitrogen. The mixture was warmed to room temperature, stirred for 16 hours and treated with methanol (35 cm3). Ethyl acetate (500 cm3) was added and the mixture filtered to remove inorganic material. The filtrate was concentrated in vacuo to afford a solid which was chromatographed on silica (Merck “MK 60.9385”) eluding wiht chloroform:methanol, 49:1 (by volume), and the requisite fractions were combined and evaporated in vacuo to give 2-amino-5-iodobenzyl alcohol, m.p. 125, (19.0 g). Analysis %: Found: C, 34.4; H, 3.2; N, 6.0; Calculated for C17 H8 INO: C, 33.8; H, 3.2; N, 5.6.
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Reference:
Patent; Pfizer Inc.; US4710507; (1987); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com