63262-06-6,Some common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, molecular formula is C6H2Br2I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To an oven dried round bottom flask was added 1 (14.5 g, 29.8 mmol) and (0206) tetrakistriphenylphosphinepalladium(O) (1.7 g, 1.5 mmol) before a 0.5 M (3-bromothiophen- 2-yl)zinc(ll) bromide solution in THF (125 ml_, 62.5 mmol) was added. The reaction mixture was stirred and heated at 65 C (oil bath temperature) overnight. The mixture was cooled to room temperature and poured into 150 ml_ of saturated aqueous ammonium chloride solution. The precipitate was filtered off and washed with water, acetone and diethyl ether. Compound 2 was recovered as an off-white solid (1 1.6 g, 20.8 mmol, 70% yield). 1 H NMR (400 MHz, CDCIs): delta 7.74 (s, 2H), 7.44 (d, J = 5.3 Hz, 2H), 7.1 1 (d, J = 5.3 Hz, 2H). 13C NMR (100 MHz, CDCI3): delta 136.63, 136.11 , 135.17, 130.51 , 126.97, 123.53, 1 11.79, 77.16. HRMS (El): m/z calcd for Ci4H6Br4S2 (M+) 557.6603 found 557.6603.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-diiodobenzene, its application will become more common.
Reference:
Patent; IMPERIAL INNOVATIONS LIMITED; WADSWORTH, Andrew; NIELSEN, Christian; HOLLIDAY, Sarah; MCCULLOCH, Iain; KNALL, Astrid-Caroline; PURUSHOTHAMAN, Balaji; (81 pag.)WO2017/191468; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com