5326-47-6, These common heterocyclic compound, 5326-47-6, name is 2-Amino-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Concentrated H2SO4 (3.7 mL) was added dropwise at 20 C under argon atmosphere to a stirred solution of 5-iodoanthranilic acid (5.0 g, 19 mmol) in MeOH (20 mL), and the mixture was refluxed for 7 h. The mixture was then concentrated in vacuo to the volume of 10 mL, poured into a vigorously stirred saturated solution of NaHCO3 (80 mL), and extracted with EtOAc. The organic layer was washed with a brine solution, dried over Na2SO4, and concentrated in vacuo; the residue was purified by chromatography on SiO2 (eluent was benzene). Ester 6 (3.68 g) was isolated as yellow crystals, m.p. 80-82 C (LP). 1H NMR (CDCl3), delta: 3.87 (s, 3 H, MeO); 5.76 (br.s, 2 H, H2N); 6.46 (d, 1 H, HC(3), J = 8.7 Hz); 7.48 (dd, 1 H, HC(4), J = 8.7 Hz, J = 2.2 Hz); 8.14 (d, 1 H, 2 HC(6), J = 2.2 Hz); which is similar to that reported previously.24
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5326-47-6.
Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com