18698-96-9, A common compound: 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Aminoester 76 (0.92 g, 4.50 mmol) and 2-(2-iodophenyl)acetic acid (1.36 g, 5.2 mmol) were dissolved in 23 ml butyl acetate. 1-Propanephosphonic anhydride solution (T3P, 7 ml, 11.7 mmol) was added and the mixture was stirred for 1 h at room termpature and then 1 h at reflux. The mixture was allowed to cool to room temperature and was washed twice with 4percent sodium bicarbonate solution. The organics were dried over anhydrous sodium sulphate, filtrered and evaporated under reduced pressure. The residue was purified using the SP-1 purification system (ethyl acetate-hexane gradient, 0:100 rising to 30:70) to give 77 (1.1 g, 2.62 mmol, 58percent yield) as a pale yellow solid. Purity 100percent. 1H NMR spectrum not recorded. UPLC/MS (3 min) retention time 1.76 min. LRMS: m/z 421 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 102 – 133;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com