2265-93-2, Name is 2,4-Difluoroiodobenzene, 2265-93-2, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
EXAMPLE 4; 2,4-Bis-(2,4-difluorophenyI)-3-l(3-pyridyl)hydroxymethyI]thiophene; To a suspension of 1.54gm (ll.lmmol) of potassium carbonate, 1.44gm (4.46mmol) of tetrabutylammonium bromide, and .05gm (0.22mmol) of palladium(II) diacetate in 1.ImL of acetonitrile/H2O (9:1) under a N2 atmosphere was added 1.83gm (6.69mmol) of 2,4-difluoro-l-iodobenzene and 0.50gm (4.46mmol) of thiorhohene-3-carboxaldehyde. The mixture was heated at 800C for 3days, and then diluted with ethyl acetate. The ethyl acetate solution was washed with water and dried over magnesium sulfate. The drying agent was filtered off, and the solvent was removed by rotoevaporation to give a red-brown solid which was purified by flash column chromatography on silica gel to give a mixture of 2-(2,4- difluorophenyl)thiophene-3-carboxaldehyde and 2,4-bis-(2,4- difluorophenyl)thiophene-3-carboxaldehyde which was used in the next reaction.
Statistics shows that 2,4-Difluoroiodobenzene is playing an increasingly important role. we look forward to future research findings about 2265-93-2.
Reference:
Patent; SYNGENTA LIMITED; WO2007/75487; (2007); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com