112671-42-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The starting material, phenylboronic acid (76.84g, 630.2mmol) was dissolved in a THF (2780ml) in a round bottom flask, 4-bromo-1-iodo-2-nitrobenzene (309.96g, 945.3mmol), Pd (PPh3) 4 ( 36.41g, 31.5mmol), was added K2CO3 (261.3g, 1890.6mmol), water (1390ml) and the resulting mixture was stirred at 80 . Once the reaction is complete, the organic layer extracted with water and CH2Cl2After the dried over MgSO4 and concentrated to a silicagel column and the resulting compound was recrystallized 122.68g product (yield: 70%)It was obtained.
The synthetic route of 4-Bromo-1-iodo-2-nitrobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Duksan Neolux Co, Ltd.; Moon, Song Yoon; Lee, Son Hui; Park, Jong Cheol; Kim, Dae Song; Lee, Bom Song; Park, Song Jae; (89 pag.)KR101550768; (2015); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com