77317-55-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, A new synthetic method of this compound is introduced below.
2-Amino-5-iodo-benzoic acid methyl ester (14.00 g) was dissolved in dry THF (50 mL) and 1 M diisobutylaluminium hydride in THF (165 mL) was added dropwise to this solution at -300C. The solution was then stirred at -15C for 1 h. To this mixture MeOH (50 mL) was added portionwise, maintaining the temperature of the solution below -5C. The resulting mixture was then left at -15C for 18 h. The formed solid was filtered off and washed with MeOH. The organic phase was dried and the solvent was evaporated in vacuo. The residue was purified by flash chromatography (silica gel, 1-5% methanol in dichloromethane) to give the title compound (9.70 g); ESMS m/z 249.9 [M+H]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.; WO2007/54296; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com