In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 82998-57-0 as follows. 82998-57-0
Add 1 equivalent of potassium t-butoxide to a 25 mL Schlenk reaction tube, add 2 mL of toluene under an argon atmosphere, stir for 30 min, remove the solvent, add 0.02 equivalent of anhydrous copper sulfate and 4.0 equivalent of potassium t-butoxide, and dry in vacuum for 15 minutes. 3 mL of benzonitrile and 1 mL of t-butanol were sequentially added under an argon atmosphere, 2 mmol of 3-iodo-4-methylbenzoic acid was in the reaction tube after adding polytetrafluoroethylene stopper was placed into an oil bath of the reaction 90 C for 24 h. After the reaction is completed, 4 equivalents of formic acid are added, and the solvent is removed by filtration and the residue is purified by column chromatography eluting with petroleum ether / methylene chloride / ethyl acetate (v: v: v = 5:10:1), 6-carboxy-2-phenyl-1H-indole was obtained as a white solid. The yield was 92%.
According to the analysis of related databases, 82998-57-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; University of Science and Technology of China; Kang Yanbiao; Shan Xianghuan; (12 pag.)CN108863894; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com