116632-39-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 116632-39-4, name is 5-Bromo-2-iodotoluene, A new synthetic method of this compound is introduced below.
To a solution of 4-bromo-l-iodo-2 -methyl -benzene (3.73 g, 12.6 mmol) in anhydrous tetrahydrofuran (20 mL) was added n-butyllithium (2.5 M, 5.02 mL) at -70 C for 30 min. Then, (¡À)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (2.00 g, 11.4 mmol) in anhydrous tetrahydrofuran (10 mL) was added at -70 C. The reaction mixture was stirred at rt for 30 min. On completion, the mixture was quenched with water (20 mL) and concentrated in vacuo to remove the organic solvent. The aqueous phase was extracted with dichlorom ethane (3 X 100 mL) and the combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by chromatography (dichloromethane:methanol = 100: 1) to give the title compound. NMR (400MHz, CDC13) delta = 7.42 – 7.30 (m, 2H), 7.04 (d, J= 8.0 Hz, 1H), 5.33 (d, J = 7.0 Hz, 1H), 5.15 (d, J= 6.8 Hz, 1H), 5.02 (d, J = 6.8 Hz, 1H), 4.90 (d, J = 7.0 Hz, 1H), 4.24 (s, 1H), 2.13 (s, 3H), 1.19 (s, 9H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com