135050-44-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 135050-44-1 as follows.
Step 1) N- (3-chloro-4-iodophenyl) methanesulfonamide To a solution of 3-chloro-4-iodoaniline (2.53 g, 10 mmol) in dichloromethane (20 mL) was added pyridine (0.87 g, 11 mmol) , followed by methylsulfonyl chloride (1.26 g, 11 mmol) at 0 . After the addition, the mixture was stirred at 0 for 2 hours. The reaction was quenched with water (20 mL) . The resulting mixture was extracted with DCM (150 mL) . The organic layer was washed with saturated aqueous NaCl (50 mL) and dried over anhydrous Na2SO4and concentrated in vacuo to give N- (3-chloro-4-iodophenyl) methanesulfonamide as a gray solid (3.0 g, 91) . MS (ESI, pos. ion) m/z: 331.8 [M+H]+.
According to the analysis of related databases, 3-Chloro-4-iodoaniline, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; XIE, Hongming; WU, Xiwei; REN, Qingyun; ZHANG, Jiancun; (236 pag.)WO2015/197028; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com