In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 76801-93-9
The white powdery product S4 (10 g, 14.2 mmol) obtained in Example 3.Dissolved in 20mL DMAc and acetonitrile mixture (1:1 volume ratio),Cool down to 10 C, control temperature below 30 C,3-chloropropanediol-(1,2) or 2-chloroethanol-1 (10.2 g, 92.3 mmol) was added dropwiseOr 9.55g, 92.3mmol), after the addition is completed, the temperature is raised to 50 C,After stirring for 3 h, it was cooled to 15 C, 20 mL of 10 mol/L NaOH aqueous solution was added dropwise, and the reaction was further stirred at 25 C for 1 h. After the reaction was completed, the pH was adjusted to 4 with dilute hydrochloric acid.Allow to stand at 0 C overnight, filter, filter cake washed with water several times,Drying (drying to constant weight at 85 C),Recrystallization (recrystallization in DMAc mixed with acetonitrile),A white gray or dark gray powder compound is obtained.
The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Calculate University; Wu Zhiping; Bai Xueyan; Wu Yuqi; (13 pag.)CN108727376; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com