116632-39-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 116632-39-4, name is 5-Bromo-2-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under argon protection, 114.4 g was added to the reaction flask2-iodo-5-bromotoluene(I),46.6 gO-aminothiophenol (II), 2 g of cuprous iodide,146.05 g of cyclohexanediamine and 200 mL of water,Mechanical stirring, oil bath 110 C, the reaction 6 h.The reaction mixture was cooled to room temperature, extracted with 200 mL * 3 ethyl acetate, 100 mL * 3 ammonia water and 100 mL * 3 purified water. The combined ethyl acetate phases were washed with 200 mL of purified water and 60 mL of aqueous ammonia,Wash with brine, dry over anhydrous sodium sulfate. The dried ethyl acetate layer was pulled dry, add 100 mL petroleum ether dissolved, stirred and cooled to -5 ~ -20 C, with a large amount of solid precipitation, filtration, the filter cake was washed with petroleum ether.The filter cake was collected and dried under reduced pressure at 40 C to giveThe yield of 2- (2-methyl-4-bromo-phenylmercapto) aniline (1Pi) was 98.04g with a yield of 85.7% and a purity of 91.3%
The synthetic route of 116632-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Ji Bell Pharmaceutical Co., Ltd.; Ding Deping; Li Zhaoguang; Feng Qi; Tang Zhiqun; Liu Jun; Jiang Bin; (10 pag.)CN107513048; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com