135050-44-1, The chemical industry reduces the impact on the environment during synthesis 135050-44-1, name is 3-Chloro-4-iodoaniline, I believe this compound will play a more active role in future production and life.
Example 55: N-(5-Chloro-2-( (E)-3-f3-( 4-fluoro-benzvl)-3,8-diaza-bicvclof3.2.110ct-8-vll-3-oxo- propenyl(at)-4-pyrazin-2-yl-phenyl)-acetamide; a) 3-Chloro-4-pvrazin-2-vl-phenylamine; 3-Chloro-4-iodo aniline (0. 349 g; 1.375 mmol ), 2- (tri-n-butylstannyl)pyrazine and (1.015 g; 2.75 mmol) PdC12(PPh3)2 (0.193 g; 0.16 mmol) are dissolved in xylene (5 ml) and refluxed for 2.5 h. The reaction mixture is taken up in TBME and extracted with 2N HCI three times. The combined HC-phases are poured on a saturated solution of saturated Na2C03 and extracted with TBME three times. The combined organic phases are dried over Na2S04, filtered and evaporated to dryness and purified via chromatography (Si02, acetone/hexanes 1/3) to yield the desired product as yellow crystals (162 mg; 57 %). 1 H-NMR (400MHz; DMSO-d6), No. (ppm) : 5.78 (s, 2H) ; 6.62 (dd, 1 H); 6.70 (d, 1H) ; 7.34 (d, 1H) ; 8.50 (d, 1 H); 8.63 (m, 1 H); 9.48 (s, 1 H). MS (m/z) ES+: 206 (MH+).
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-4-iodoaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/103054; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com