696-41-3, name is 3-Iodobenzaldehyde, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 696-41-3
To a mixture of compound 1 (326 mg, 2.5 mmol), compound 214 (582 mg, 2.5 mmol), and PdCl2(PPh3)2 (37 mg, 0.05 mmol) in a flame-dried Schlenk tube were added THF (15 mL) and Et3N (5 mL) under argon atmosphere and followed by the addition of CuI (10 mg, 0.05 mmol) 10 min later. The mixture was stirred at room temperature for 9 h and then water (20 mL) and brine (20 mL) were added. After being extracted with ethyl acetate (3¡Á30 mL), the combined organic phase was washed with brine and dried over sodium sulfate. Upon removal of the solvent under reduced pressure, the resulting residue was purified by column chromatography (petroleum ether/dichloromethane 1:1) to give compound 3 as a pale yellow solid (487 mg, 83%). Mp 77-78 C. 1H NMR (300 MHz, CDCl3): delta 7.49 (t, J=7.2 Hz, 1H), 7.54-7.64 (m, 2H), 7.67 (d, J=7.5 Hz, 1H), 7.81 (d, J=7.5 Hz, 1H), 7.90 (d, J=7.5 Hz, 1H), 7.96 (d, J=7.5 Hz, 1H), 8.07 (s, 1H), 10.03 (s, 1H), 10.63 (s, 1H). 13C NMR (100 MHz, CDCl3): delta 86.4, 94.5, 123.6, 126.0, 127.6, 129.1, 129.3, 129.7, 132.9, 133.4, 133.9, 135.9, 136.6, 137.1, 191.3, 191.3. MS (EI): m/z 234 [M]+. HRMS (EI): calcd for C16H10O2 [M]+: 234.0681, found 234.0687. IR (KBr, cm-1): 3064, 2834, 2732, 2208, 1703, 1591, 1284, 1200.
Statistics shows that 696-41-3 is playing an increasingly important role. we look forward to future research findings about 3-Iodobenzaldehyde.
Reference:
Article; Wang, Liu-Gang; Zhan, Tian-Guang; Zhao, Xin; Jiang, Xi-Kui; Li, Zhan-Ting; Tetrahedron; vol. 68; 26; (2012); p. 5303 – 5310;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com