Statistics shows that 18698-96-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-Iodophenyl)acetic acid.
18698-96-9, name is 2-(2-Iodophenyl)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 18698-96-9
(1-bis) A suspension of 2-iodophenyl acetic acid (Ig, 3.82 mmol), 4-bromobenzenethiol (0.722 g, 3.82 mmol), KOH (0.427 g, 7.63 mmol) and copper powder (24 mg, 0.38 mmol) in 2 mL of water, was allowed to react in microwave(conditions: 2x 6 min, 180 W, T max=100¡ãC, P max=100 psi) .The suspension obtained was dissolved in 2N aqueous solution of KOH and then filtered. The filtrate was acidified with IN aq. HCl; the white precipitate was filtered, dried in vacuo, purified by trituration with acetone to give the pure acid 1-bis as white solid (l.ldeltag, 94percent) .1H-NMR (CDCl3, 200MHz): 7.44 (d, J= 7Hz, IH); 7.36-7.26 (m, 5H); 7.01 (d, J= 8.4Hz, 2H); 3.86 (s, 2H). Anal. Calcd. for Ci4H11BrO2S (MW=323.2): C 52.03; H 3.43; Br 24.72; O 9.90; S 9.92.; Example 62- (2-biphenyl-4-ylthio) phenyl) acetic acid (19a), 2- (2- (4- methoxyphenylthio) phenyl) acetic acid (19b), 2- (2-biphenyl-4- ylthio) phenyl) -N-hydroxyacetamide (21a), N-hydroxy-2- (2- (4- methoxyphenylthio) phenyl) acetamide (21b) and 2- (2- (4- (but-2- iniloxy) phenylthio) phenyl) -N-hydroxyacetamide (21c); (16) Compound 16 was synthesized according to the procedure described for the preparation of 10, starting from o-iodophenylacetic acid (5 g, 19.08 mmol) and 4- bromobenzenethiol (2.4 g, 19.08 mmol) into 5 portions of 1 g each. The obtained suspension was collected and diluted in KOH 2N. The obtained suspension was filtered and acidified with HCl IN. The formed precipitate was brought to dryness under reduced pressure at 500C. There were recovered 4.37 g of 16 (88percent, white solid) . 1H-NMR (de-DMSO, 200MHz ) : 3 . 74 ( s , 2H) , 7 . 07 (d, J=8Hz , 2H) , 7 . 30 -7 . 42 (m, 4H) 7 . 4 9 (d, J=8Hz , 2H) , 12 . 34 (br . s , IH) .
Statistics shows that 18698-96-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-Iodophenyl)acetic acid.
Reference:
Patent; BRACCO IMAGING SPA; UNIVERSITA DI PISA; WO2008/15139; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com