74-88-4, These common heterocyclic compound, 74-88-4, name is Iodomethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
UA-1 (100 mg, 0.22 mmol) was dissolved in DMF, then K2CO3(30.0mg,0.22mmol) and three drops of iodomethane were added at room temperature.The reaction end was monitored by TLC. After completion of reaction, the mixture was extracted with ethyl acetate and washed with saturated brine, dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a white solid. The crude product was purified by column chromatography on silica gel with petroleumether-ethyl acetate (10:1) to obtain compound 2a, with a yield of 80.1%. m.p. 166.8-168.1C; ESI-MS: m/z 469.5[M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 74-88-4.
Reference:
Article; Meng, Yan-Qiu; Zhang, Liang-Feng; Liu, Dong-Ying; Liu, Li-Wei; Zhang, Yi; Zhao, Min-Jie; Journal of Asian Natural Products Research; vol. 18; 3; (2016); p. 280 – 288;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com