5398-69-6, A common heterocyclic compound, 5398-69-6, name is 2-Iodo-3-nitrobenzoic acid, molecular formula is C7H4INO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 116 methyl 2-iodo-3-nitrobenzoate A mixture of 2-iodo-3-nitrobenzoic acid (31.0 g, 106 mmol) and concentrated sulfuric acid (24.9 mL, 317 mmol) in methanol (600 mL) was heated under reflux for 12 hr. The solvent was evaporated under reduced pressure and the residue was extracted with methylene chloride. The extract was washed with saturated aqueous sodium hydrogen carbonate solution and water, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by recrystallization (chloroform /hexane) to give the title compound (31.0 g, yield 95%). 1H-NMR (DMSO-d6) delta: 3.90 (3H, s), 7.70 (1H, t, J = 7.6 Hz), 7.82 (1H, dd, J = 7.6, 1.2 Hz), 7.98 (1H, dd, J = 7.6, 1.2 Hz).
The synthetic route of 5398-69-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2141150; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com